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MIRAPEX Safety

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MANAGING PARKINSON'S DISEASE AT EVERY STAGE

Advanced Stages

Symptoms that may appear later

Parkinson's disease is a disease that progresses over time. Over many years, its symptoms become more noticeable and more symptoms appear. This is why talking to your doctor about treatment is so important. The following symptoms may or may not be seen in more advanced stages of the disease:⁹

Facial masking

This can occur if muscles in the face become rigid. A still facial expression with fewer blinks of the eyes can result. With successful treatment, however, this symptom sometimes disappears.

Difficulty swallowing

This can happen if the person has less control over the muscles in the back of his or her throat. However, severe difficulty in swallowing is rare.

MIRAPEX may help

The good news is that prescription MIRAPEX has been shown to be effective in treating patients with some of these symptoms.¹³ MIRAPEX may lessen the slowness, stiffness, and tremor you may be having.^12,18,19 Daily activities may be easier–writing letters to friends, playing with your grandchildren, or simply having a cup of tea.

MIRAPEX is the most commonly prescribed prescription dopamine agonist (DOPE-a-meen AG-oh-nist).²⁰ It is used to reduce and relieve the symptoms of Parkinson's disease. Ask your doctor whether it may be right for you.

KEY POINTS
Parkinson's disease progresses over time Symptoms gradually become more noticeable, and more of them appear Symptoms may include facial masking, speech difficulty, and difficulty swallowing If you have Parkinson's disease, ask your doctor about MIRAPEX

Next: Young Onset Parkinson's Disease (YOPD)

Important Information about MIRAPEX: MIRAPEX is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease (PD).

MIRAPEX may cause you to fall asleep without any warning, even while doing normal daily activities, such as driving. Before taking MIRAPEX, talk to your doctor if you drink alcohol or take other medications that make you drowsy as these can increase the chance that MIRAPEX will make you feel sleepy or fall asleep when you should be awake. When taking MIRAPEX, hallucinations (seeing, hearing, feeling, or tasting something that isn’t there) may occur and you may sometimes feel dizzy, nauseated, faint or sweaty when you sit up or stand quickly.

In clinical trials for early PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are nausea, dizziness, sleepiness, difficulty falling asleep, involuntary movement, and constipation. In clinical trials for advanced PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are low blood pressure when you sit up or stand quickly, involuntary movement, difficulty falling asleep, dizziness, accidental injury, hallucinations, and dream abnormalities. You should talk with your doctor if you experience these problems.

There have been reports of impulse control disorders and compulsive behaviors in patients taking certain medicines, including MIRAPEX. If you or your family members notice that you are experiencing new or increased gambling urges, increased sexual urges or other intense urges, such as compulsive shopping or eating, while taking MIRAPEX, talk to your doctor.

Please see full Prescribing Information.

This information is intended for U.S. residents only.