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MIRAPEX for Parkinson's Disease
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*Doctor portrayal

MANAGING PARKINSON'S DISEASE AT EVERY STAGE

The Stages of Parkinson's Disease

Charting the disease's progress

Doctors often describe Parkinson's disease in terms of stages. These stages describe the major symptoms and degree of disability a person has due to the progress of the disease. It is important to have a sense of what stage of disease your loved one is in so you will know what kind of symptoms to expect and what other support may be needed. (See table below.)

Stage Symptoms
I
II
III
  • First signs of loss of balance
  • Person is still fully independent
IV
  • Person may need help with some or all everyday activities
  • Person is unable to live alone without assistance
V
  • Person is confined to a wheelchair or bed unless assisted

Early stages of Parkinson's disease: I to III

Early symptoms of Parkinson's disease develop slowly and may include feeling tired or "shaky." Although the rate of disease progression varies from person to person, people usually progress from Stages I to II in about 18 months, and from Stages II to III in roughly 25 months.16

Sometimes getting in and out of a chair may become difficult or walking appears stiff and unnatural. You may begin to see your loved one shuffling; handwriting may become cramped and the script may be small. The patient's face may begin to lose expression and animation, and the patient may occasionally remain in one position for an extended period of time.17

Advanced stages of Parkinson's disease: IV and V

As Parkinson's disease progresses and the patient loses more muscle control, he or she may have difficulty swallowing. You may notice speech problems such as talking very softly or in a monotone, slurring of words, hesitation, or speaking too quickly. Some people may develop urinary problems or constipation. Their skin and scalp may become oily because of a malfunctioning autonomic nervous system.9 Problems sleeping, drowsiness during the day, and nightmares may also occur.

Symptoms may become more pronounced and difficult to manage. (These symptoms tend to develop much later in the disease.) They may include problems maintaining balance, periods of confusion, hallucinations, and in some cases, dementia. In general, people progress from Stages III to IV in about 42 months, and from Stages IV to V in about 17 months.16

Next: Read about the early stages of Parkinson's disease

 

Important Information about MIRAPEX: MIRAPEX is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease (PD).

MIRAPEX may cause you to fall asleep without any warning, even while doing normal daily activities, such as driving. Before taking MIRAPEX, talk to your doctor if you drink alcohol or take other medications that make you drowsy as these can increase the chance that MIRAPEX will make you feel sleepy or fall asleep when you should be awake. When taking MIRAPEX, hallucinations (seeing, hearing, feeling, or tasting something that isn’t there) may occur and you may sometimes feel dizzy, nauseated, faint or sweaty when you sit up or stand quickly.

In clinical trials for early PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are nausea, dizziness, sleepiness, difficulty falling asleep, involuntary movement, and constipation. In clinical trials for advanced PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are low blood pressure when you sit up or stand quickly, involuntary movement, difficulty falling asleep, dizziness, accidental injury, hallucinations, and dream abnormalities. You should talk with your doctor if you experience these problems.

There have been reports of impulse control disorders and compulsive behaviors in patients taking certain medicines, including MIRAPEX. If you or your family members notice that you are experiencing new or increased gambling urges, increased sexual urges or other intense urges, such as compulsive shopping or eating, while taking MIRAPEX, talk to your doctor.

Please see full Prescribing Information.

This information is intended for U.S. residents only.