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MANAGING PARKINSON'S DISEASE AT EVERY STAGE

Young Onset Parkinson's Disease (YOPD)

An earlier arrival of symptoms

About 8% to 10% of patients with Parkinson's disease have symptoms that appear before the age of 40.22 People who develop symptoms of the disease between the ages of 20 through 40 are said to have "Young Onset Parkinson's Disease (YOPD)."4,21

Most of the cardinal symptoms of Parkinson's disease—such as bradykinesia, difficulty with walking, and rigidity—are seen in people of all ages. But one study found a key difference between young onset Parkinson's disease and Parkinson's disease in older patients: tremor is seen somewhat less often in younger patients than in those diagnosed in their 60s or later.4

Muscle spasms that cause abnormal postures, such as arching of the foot (called dystonia) are more common in the young-onset patient. These often appear before other, more typical symptoms of Parkinson's disease appear.21 However, patients with Young Onset Parkinson's Disease are less likely to have dementia.4

Treatment-related complications in Young Onset Parkinson's Disease

Movement disorders and other treatment-related complications due to levodopa are more common in younger Parkinson's disease patients, not because they are different than other Parkinson's disease patients but simply because these patients are on levodopa therapy longer.4 Levodopa is still the most effective treatment for Parkinson's disease; however, the motor complications associated with long-term levodopa therapy can be disabling. But if you have Young Onset Parkinson's Disease, your doctor may want to delay the use of this medicine or use the lowest dose possible to avoid these complications.24 Using a dopamine agonist such as MIRAPEX may be one effective way to do that.21

As with older onset Parkinson's disease, how fast and how quickly Young Onset Parkinson's Disease progresses can vary greatly among individuals. Most clinical symptoms are the same at whatever age Parkinson's disease develops. But management may be very different for young-onset patients because of the concerns that come from having these symptoms at a young age.21

Getting treatment for Young Onset Parkinson's Disease

If you or someone you care for has Young Onset Parkinson's, it's a good idea to find a doctor who has experience treating these patients. This way, the doctor will be familiar with the best ways to achieve long-term control of symptoms. The doctor will also be able to offer strategies and techniques to help the patient keep the highest level of independence possible for the longest possible time.

Psychological and social issues

Getting a diagnosis of a chronic disorder like Parkinson's disease is tough at any age. But it can be especially difficult for a teenager or young adult, who still has their whole life ahead of them.25 They will be concerned about their future, and whether or not they'll be able to ever have a family, a successful career, or a fulfilling life in general. They may also be frightened by the idea of a lifetime of increasing medical bills and decreasing abilities.

Read more about special issues related to YOPD:

Effects on the family

After getting the diagnosis, patients with Young Onset Parkinson's Disease may have many questions. The ongoing need for lifestyle changes can also affect relationships between the different family members. Therefore, in families who experience Young Onset Parkinson's Disease, it can be extra helpful to consider family counseling to make sure any issues are dealt with quickly and thoroughly.
People who develop Young Onset Parkinson's Disease who are raising children may face some additional challenges. Children may ask questions about the condition. Parents with Young Onset Parkinson's Disease should prepare simple, reassuring and honest answers to any questions they may have. Many national Parkinson's disease organizations have materials that can help families learn about Parkinson's disease together.

Career issues

The good news is that medicines such as levodopa and MIRAPEX have greatly improved treatment and delayed difficulties for the majority of patients with Parkinson's disease. All people with Parkinson's disease, but especially those with Young Onset Parkinson's Disease, need to remember that Parkinson's disease progresses slowly over many years. If they begin treatment and stay with it, they will most likely have many years of work ahead of them. In later years, the person will have to decide just how long they want to continue working and when to apply for medical disability.22

Effects on sexuality & intimacy

In Young Onset Parkinson's Disease, some symptoms can reduce a person's interest in sex and reduce the degree of sexual activity in people with Parkinson's disease. In addition, the patient's sexual partner also may experience fatigue as they struggle with the responsibility of caring for their partner. They may have neither the energy for nor any interest in sexual activity. Also, some symptoms may cause the person with Parkinson's disease to appear less physically attractive.26 If you have Young Onset Parkinson's Disease, your doctor can refer you to other specialists, such as a urologist, gynecologist, or sex therapist, to help identify issues affecting sexuality and offer practical solutions.



For more information about Young Onset Parkinson's Disease, and how to get help with coping, visit www.youngparkinsons.org/, a Web site devoted to the needs of YOPD patients and their care partners.

KEY POINTS
  • Young Onset Parkinson's Disease has the same range of symptoms as late onset Parkinson's disease, except:

    - Tremor may be less common

    - Dystonias may be more common
  • Treatment-related motor complications may be more common
  • These patients have different needs because symptoms are more difficult to deal with at this stage in life
  • It is helpful to find a doctor who has experience treating patients with Young Onset Parkinson's Disease

Next: Treatment of Parkinson's disease with MIRAPEX

 

Important Information about MIRAPEX: MIRAPEX is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease (PD).

MIRAPEX may cause you to fall asleep without any warning, even while doing normal daily activities, such as driving. Before taking MIRAPEX, talk to your doctor if you drink alcohol or take other medications that make you drowsy as these can increase the chance that MIRAPEX will make you feel sleepy or fall asleep when you should be awake. When taking MIRAPEX, hallucinations (seeing, hearing, feeling, or tasting something that isn’t there) may occur and you may sometimes feel dizzy, nauseated, faint or sweaty when you sit up or stand quickly.

In clinical trials for early PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are nausea, dizziness, sleepiness, difficulty falling asleep, involuntary movement, and constipation. In clinical trials for advanced PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are low blood pressure when you sit up or stand quickly, involuntary movement, difficulty falling asleep, dizziness, accidental injury, hallucinations, and dream abnormalities. You should talk with your doctor if you experience these problems.

There have been reports of impulse control disorders and compulsive behaviors in patients taking certain medicines, including MIRAPEX. If you or your family members notice that you are experiencing new or increased gambling urges, increased sexual urges or other intense urges, such as compulsive shopping or eating, while taking MIRAPEX, talk to your doctor.

Please see full Prescribing Information.

This information is intended for U.S. residents only.