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Caring for Someone
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MANAGING PARKINSON'S DISEASE AT EVERY STAGE

Treatment of Parkinson's Disease with MIRAPEX

MIRAPEX is effective in both early and late stages of Parkinson's disease

MIRAPEX is a drug that is approved by the FDA for treating the signs and symptoms of Parkinson's disease.¹⁰ In a clinical study, patients recently diagnosed with Parkinson's disease had improvement in their activities of daily living.

MIRAPEX can be used alone, or in combination with other therapies, and is effective in treating both early and advanced stages of the disease.^11,12

When used as initial therapy, it helps patients maintain their everyday activities.¹⁸ MIRAPEX may be used as a single therapy during the early stages of Parkinson's disease. In fact, after 4 years of pramipexole therapy in a clinical study, there was a 41% chance of remaining on MIRAPEX alone without the need to add levodopa.¹¹ Levodopa may then be reserved, often for several years, until needed. (Levodopa therapy significantly improves symptoms for most patients. However, as the disease advances, the benefits of the drug last for shorter and shorter periods of time.²⁷)

A levodopa-friendly therapy

MIRAPEX also may be used with levodopa therapy. This may allow patients to take a lower dose of levodopa. Using MIRAPEX in combination with levodopa therapy may help make the benefits of levodopa therapy last longer. Studies show that when MIRAPEX is added to levodopa therapy, patients have improved functioning. MIRAPEX increased the patients' daily "on" time, or time when symptoms are generally controlled, by as much as 2 hours.^12,13

MIRAPEX has been shown to be very effective in improving tremor. A study showed that the majority of patients taking MIRAPEX saw an improvement in tremor symptoms.¹⁹

To find out if MIRAPEX is right for you or your loved one, talk with your doctor. Print this page and bring it to your next visit.

Patients and care partners should be informed that impulse control disorders/compulsive behaviors may occur while taking medicines, including MIRAPEX, to treat Parkinson's disease.

KEY POINTS
MIRAPEX: may treat the signs and symptoms of Parkinson's disease may be used alone or in combination with other therapies, including levodopa

Next: Learn more about how MIRAPEX works

Important Information about MIRAPEX: MIRAPEX is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease (PD).

MIRAPEX may cause you to fall asleep without any warning, even while doing normal daily activities, such as driving. Before taking MIRAPEX, talk to your doctor if you drink alcohol or take other medications that make you drowsy as these can increase the chance that MIRAPEX will make you feel sleepy or fall asleep when you should be awake. When taking MIRAPEX, hallucinations (seeing, hearing, feeling, or tasting something that isn’t there) may occur and you may sometimes feel dizzy, nauseated, faint or sweaty when you sit up or stand quickly.

In clinical trials for early PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are nausea, dizziness, sleepiness, difficulty falling asleep, involuntary movement, and constipation. In clinical trials for advanced PD, the most commonly reported side effects of MIRAPEX that were more frequent than with placebo are low blood pressure when you sit up or stand quickly, involuntary movement, difficulty falling asleep, dizziness, accidental injury, hallucinations, and dream abnormalities. You should talk with your doctor if you experience these problems.

There have been reports of impulse control disorders and compulsive behaviors in patients taking certain medicines, including MIRAPEX. If you or your family members notice that you are experiencing new or increased gambling urges, increased sexual urges or other intense urges, such as compulsive shopping or eating, while taking MIRAPEX, talk to your doctor.

Please see full Prescribing Information.

This information is intended for U.S. residents only.